Related Experiment Video
Updated: Aug 23, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
Presynaptic induction and expression of NMDA-dependent LTP
1Center for Molecular and Behavioral Neuroscience, Rutgers State University, 197 University Avenue, Newark, NJ 07102, USA. pare@axon.rutgers.edu
Abstract:
It is almost axiomatic in neuroscience that postsynaptically induced NMDA-dependent long-term potentiation (LTP) is a cellular substrate of memory. As a result, memory impairments caused by experimental reductions of NMDA currents are often interpreted as evidence that this form of plasticity is involved in memory formation. However, a recent Nature study indicates that not all NMDA-dependent LTP is induced postsynaptically.
More Related Videos
Related Concept Videos
Long-term Potentiation
Long-term Potentiation
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression
Excitatory and Inhibitory Effects of Neurotransmitters
Integration of Synaptic Events

