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Updated: Aug 23, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

Hydrochlorothiazide induced hepato-cholestatic liver injury

Zeev Arinzon1, Peisakh Alexander, Yitshal Berner

  • 1Meuhedet Health Care System, Netania, Israel. arinzon@walla.co.il

Age and Ageing
|July 24, 2004
PubMed

Insights

Hydrochlorothiazide, a common hypertension drug, can cause severe liver damage. This case highlights a rare but serious risk associated with this widely used diuretic medication.

Area of Science:

  • Pharmacology
  • Hepatology
  • Cardiology

Background:

  • Hydrochlorothiazide is a first-line treatment for uncomplicated arterial hypertension.
  • Thiazide diuretics are commonly prescribed for managing high blood pressure.

Observation:

  • Several reports link thiazide use to cholecystitis.
  • This study details a case of significant hepatotoxicity.

Findings:

  • The patient experienced serious liver injury attributed to hydrochlorothiazide.
  • This adverse event underscores a potential risk beyond gall bladder inflammation.

Implications:

  • Clinicians should consider liver function when prescribing hydrochlorothiazide.
  • Awareness of hydrochlorothiazide-induced hepatotoxicity is crucial for patient safety.

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