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Inhibition of nitric oxide synthase exacerbates group B streptococcus sepsis and arthritis in mice
Manuela Puliti1, Christina von Hunolstein, Francesco Bistoni
1Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
Infection and Immunity
|July 24, 2004
Abstract:
The role of nitric oxide in group B Streptococcus (GBS) infection was evaluated by inhibiting its production with aminoguanidine (AG). AG-treated mice displayed higher mortality rates and more frequent and severe arthritis than controls. Worsening of arthritis correlated with a higher number of GBS cells in the joints and local interleukin-1 beta production.
