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Updated: Aug 23, 2026

Intradermal Inoculation of Mycobacterium avium in the Mouse Ear
Published on: July 3, 2025
Genetic diversity of the dnaJ gene in the Mycobacterium avium complex
Yukio Morita1, Soichi Maruyama1, Hidenori Kabeya1
1Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma, Japan 2Laboratory of Veterinary Public Health, Department of Veterinary Medicine, College of Bioresource Science, Nihon University, Fujisawa, Kanagawa, Japan 3Department of Pediatrics, Gunma University, School of Medicine, Maebashi, Gunma, Japan 4Laboratory of Food Microbiology and Hygiene, Takasaki University of Health and Welfare, Takasaki, Gunma, Japan.
Abstract:
The Mycobacterium avium complex (MAC) is associated with various diseases in humans as a zoonosis. The dnaJ gene was partially sequenced in Schaefer's 28 reference strains of MAC, 14 human MAC isolates and 22 veterinary isolates. From substitutions affecting 21-32 nucleotides, all strains could be classified into 14 groups. Most nucleotide substitutions did not alter amino acid sequences. Approximately 8 % genetic diversity was seen in these strains, which divided into two clusters: cluster I (0.8 % genetic diversity), comprising the reference strain serotypes 1-6, 8-11 and 21 and all isolates; and cluster II (7 % genetic diversity), comprising the remaining reference strains. Analysis of the dnaJ gene in MAC may be useful in epidemiological studies.
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