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Updated: Aug 23, 2026

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
Published on: September 18, 2017
Calcium cycling proteins in heart failure, cardiomyopathy and arrhythmias
Susumu Minamisawa1, Yoji Sato, Myeong-Chan Cho
1Department of Physiology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan. sminamis@med.yokohama-cu.ac.jp
Abstract:
A growing body of evidence, including studies using genetically engineered mouse models, has shown that Ca2+ cycling and Ca2+-dependent signaling pathways play a pivotal role in cardiac hypertrophy and heart failure. In addition, recent studies identified that mutations of the genes encoding sarcoplasmic reticulum (SR) proteins cause human cardiomyopathies and lethal ventricular arrhythmias. The regulation of Ca2+ homeostasis via the SR proteins may have potential therapeutic value for heart diseases such as cardiomyopathy, heart failure and arrhythmias.
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