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High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
Published on: January 4, 2015
Stem cell therapy for human neurodegenerative disorders-how to make it work
Olle Lindvall1, Zaal Kokaia, Alberto Martinez-Serrano
1Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Department of Clinical Neuroscience, Wallenberg Neuroscience Center, University Hospital, SE-221 84 Lund, Sweden. olle.lindvall@neurol.lu.se
Abstract:
Recent progress shows that neurons suitable for transplantation can be generated from stem cells in culture, and that the adult brain produces new neurons from its own stem cells in response to injury. These findings raise hope for the development of stem cell therapies in human neurodegenerative disorders. Before clinical trials are initiated, we need to know much more about how to control stem cell proliferation and differentiation into specific phenotypes, induce their integration into existing neural and synaptic circuits, and optimize functional recovery in animal models closely resembling the human disease.
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