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Related Experiment Videos

Spacing patterns on tongue surface-gustatory papilla.

Han-Sung Jung1, Keiichi Akita, Jae-Young Kim

  • 1Division of Anatomy and Developmental Biology, Department of Oral Biology, College of Dentistry, Yonsei University, Seoul, Korea. hsjung@yumc.yonsei.ac.kr

The International Journal of Developmental Biology
|July 24, 2004
PubMed
Summary

Mammalian tongues have four papillae types, with fungiform papillae showing patterned development similar to other epithelial appendages. Studying fungiform papillae organogenesis offers insights into developmental spacing and epithelial-mesenchymal interactions.

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Area of Science:

  • Developmental biology
  • Oral biology
  • Epithelial biology

Background:

  • Mammalian tongues possess four papillae types: fungiform, circumvallate, foliate, and filiform.
  • Gustatory papillae (fungiform, circumvallate, foliate) house taste buds and exhibit distinct spatial patterning on the tongue.
  • Fungiform papillae, located anteriorly, are arranged in a stereotyped pattern, suggesting developmental similarities to other epithelial appendages like teeth and hair.

Purpose of the Study:

  • To investigate the developmental processes and patterned distribution of fungiform papillae on the mammalian tongue.
  • To explore the similarities between fungiform papillae development and other epithelial appendages.
  • To determine if fungiform papillae organogenesis serves as a model for understanding developmental spacing and epithelial-mesenchymal interactions.

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Main Methods:

  • Analysis of gene expression patterns for signaling molecules during fungiform papillae development.
  • Observation of early developmental structures, including epithelial thickening and mesenchymal condensation.
  • Examination of reciprocal interactions between epithelial and mesenchymal tissues during morphogenesis.

Main Results:

  • Signaling molecules are expressed in stereotyped patterns in areas forming fungiform papillae prior to morphological changes.
  • Early fungiform papillae development involves characteristic structures like epithelial thickening and mesenchymal condensation.
  • Fungiform papillae formation is driven by reciprocal signaling between epithelial and mesenchymal components.

Conclusions:

  • The patterned distribution and developmental mechanisms of fungiform papillae resemble those of other epithelial appendages.
  • Fungiform papillae development provides a valuable model for studying epithelial-mesenchymal interactions.
  • Early organogenesis of fungiform papillae is a suitable system for understanding developmental spacing patterns in embryogenesis.