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[Molecular-target drug].

Saburo Sone1, Seiji Yano, Yasuhiko Nishioka

  • 1Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosiences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|July 27, 2004
PubMed
Summary

Biomarkers are crucial for evaluating new molecular-targeted cancer drugs, which often have cytostatic effects. This review discusses the significance and challenges of using biomarkers in clinical trials for targeted cancer therapeutics.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Context:

  • Cancer metastasis involves complex processes like tumor growth, angiogenesis, invasion, and adhesion.
  • Molecular-targeted drugs aim to inhibit specific molecules driving cancer progression.
  • Clinical evaluation of these drugs faces challenges due to their cytostatic, rather than cytocidal, mechanisms.

Purpose:

  • To review the significance of biomarkers in the clinical evaluation of molecular-targeted cancer drugs.
  • To discuss the challenges associated with using biomarkers for efficacy assessment in early-phase clinical trials.
  • To explore how genomics and proteomics can expand the repertoire of targeted therapeutics.

Summary:

  • Molecular-targeted cancer drugs offer new therapeutic avenues but pose challenges in efficacy evaluation.

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  • Biomarkers are essential for assessing the clinical benefit of cytostatic targeted agents.
  • Genomics and proteomics are advancing the development and evaluation of novel targeted therapies.

    • Impact:

    • Improved clinical trial design for molecular-targeted drugs.
    • Enhanced ability to predict patient response to targeted therapies.
    • Facilitation of personalized medicine approaches in oncology.