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Related Experiment Videos

Effects of creatine supplementation on renal function.

Wyndie M Yoshizumi1, Candy Tsourounis

  • 1Cedars-Sinai Medical Center, Los Angeles, CA., USA.

Journal of Herbal Pharmacotherapy
|July 27, 2004
PubMed
Summary

Creatine supplementation is generally safe for healthy adults at recommended doses. However, individuals with pre-existing kidney disease or those on certain medications should exercise caution due to potential renal dysfunction risks.

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Area of Science:

  • Sports Medicine
  • Nephrology
  • Nutritional Science

Background:

  • Creatine is a widely used supplement for enhancing athletic performance.
  • Concerns exist regarding its impact on kidney health.
  • A comprehensive review of existing literature is needed.

Purpose of the Study:

  • To evaluate the effects of creatine supplementation on renal function.
  • To identify potential risks associated with creatine use.

Main Methods:

  • A systematic literature search was conducted using PubMed.
  • Keywords included: creatine, supplementation, renal dysfunction, ergogenic aid, and renal function.
  • Twelve relevant articles and case reports were analyzed.

Main Results:

  • Creatine supplementation appears safe for healthy adults at recommended loading and maintenance doses.
  • Individuals with a history of kidney disease or on nephrotoxic medications may face increased renal dysfunction risk.
  • A case of acute renal failure was reported in a young adult exceeding recommended doses.
  • Long-term safety data for high doses and safety in children/adolescents are limited.
  • Creatine may elevate creatinine levels, potentially mimicking renal dysfunction.

Conclusions:

  • Creatine supplementation is likely safe for healthy adults within recommended dosages.
  • Caution is advised for individuals with pre-existing renal conditions or those on specific medications.
  • Further research is needed on long-term high-dose creatine use and its safety in younger populations.
  • Alternative renal function markers beyond serum creatinine are recommended for future studies.

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