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Anticancer activities of Oldenlandia diffusa
Salin Gupta1, David Zhang, Jizu Yi
1Department of Pharmacy & Administrative Sciences, College of Pharmacy & Allied Health Professions, St. John's University, Jamaica, NY., USA.
Journal of Herbal Pharmacotherapy
|July 27, 2004
Summary
Oldenlandia diffusa, a Chinese herb, shows potent anticancer effects by inhibiting cancer cell growth and inducing apoptosis. This herb extract effectively reduced lung metastasis in mice with minimal toxicity to normal cells, suggesting its potential as an anticancer agent.
Area of Science:
- Phytochemistry
- Cancer Biology
- Pharmacology
Background:
- Traditional Chinese Medicine utilizes Oldenlandia diffusa (Bai Hua She She Cao) for various ailments.
- Understanding the scientific basis of its therapeutic properties is crucial.
Purpose of the Study:
- To investigate the anticancer activities of Oldenlandia diffusa water extract.
- To evaluate its efficacy and safety in preclinical models.
Main Methods:
- In vitro anti-proliferative assays against eight cancer cell lines and one normal cell line.
- Apoptosis induction analysis using microscopy and DNA ladder assays.
- In vivo efficacy study in C57BL/6j mice with B16-F10 lung metastasis.
Main Results:
- The extract demonstrated strong anti-proliferative activity against all tested cancer cell lines (IC50: 7-25 mg/mL).
- Significant apoptosis induction was observed in cancer cells.
- Oral administration reduced lung metastases by 70% (p < 0.001) with minimal toxicity to normal pancreatic cells.
Conclusions:
- Oldenlandia diffusa extract exhibits significant anticancer properties, inhibiting cancer cell proliferation and inducing apoptosis.
- The extract shows a favorable safety profile with minimal toxicity to normal cells.
- It holds promise as a potential natural anticancer therapeutic agent.