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Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183
Soo-Yon Rhee1, Tommy Liu, Jaideep Ravela
1Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, California, USA.
Antimicrobial Agents and Chemotherapy
|July 27, 2004
Abstract:
In a sample of 6,156 sequences from 4,183 persons, the top 30 patterns of protease inhibitor, nucleoside reverse transcriptase (RT) inhibitor, and nonnucleoside RT inhibitor mutations accounted for 55, 46, and 66%, respectively, of sequences with drug resistance mutations. Characterization of the phenotypic and clinical significance of these common patterns may lead to improved treatment recommendations for a large proportion of patients for whom antiretroviral therapy is failing.