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Magnetic resonance imaging: significance of early ischemic changes on computed tomography

Laurent Derex1, Norbert Nighoghossian, Marc Hermier

  • 1Cerebrovascular Disease Center, Hôpital Neurologique, Hospices Civils de Lyon, Lyon, France.

Cerebrovascular Diseases (Basel, Switzerland)
|July 27, 2004
PubMed
Abstract

Insights

Early ischemic changes (EICs) on CT scans indicate a larger acute lesion volume on diffusion-weighted imaging (DWI) MRI in acute ischemic stroke patients. This finding helps clarify the significance of EICs in stroke assessment.

Area of Science:

  • Neurology
  • Radiology
  • Stroke Imaging

Background:

  • The clinical significance of early ischemic changes (EICs) detected on computed tomography (CT) in acute ischemic stroke is debated.
  • Magnetic resonance imaging (MRI) may offer crucial insights into these early changes.

Purpose of the Study:

  • To investigate the relationship between early ischemic changes (EICs) on CT and MRI parameters in acute ischemic stroke patients.
  • To determine if EICs on CT correlate with acute lesion volume on diffusion-weighted imaging (DWI).

Main Methods:

  • Patients with acute ischemic stroke underwent CT and MRI, including DWI, upon presentation.
  • EICs on CT were graded, and their association with MRI parameters was statistically analyzed.
  • Statistical methods included one-way ANOVA and the chi2 test.

Main Results:

  • Forty-eight patients were analyzed; EICs were absent in 28, present in <33% of the MCA territory in 15, and >33% in 5.
  • Patients with EICs covering >33% of the MCA territory had higher NIHSS scores.
  • Major EICs correlated with significantly larger acute lesion volumes on DWI (140 cm³ vs 33 cm³).

Conclusions:

  • Early ischemic changes (EICs) on CT are primarily indicative of a larger acute lesion volume on diffusion-weighted imaging (DWI).
  • MRI provides valuable information regarding the extent of early ischemic injury suggested by CT findings.

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