Human papillomavirus infections in children

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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

Nanette B Silverberg1

  • 1Department of Pediatric Dermatology, St. Luke's-Roosevelt Hospital Center, New York, New York, USA. nsilverberg@juno.com

Current Opinion in Pediatrics
|July 27, 2004
PubMed

Insights

Human papillomavirus (HPV) causes warts in children, often resolving spontaneously. New destructive, immunologic therapies, and vaccines offer future containment of HPV infections and related oncogenesis.

Area of Science:

  • Virology
  • Immunology
  • Dermatology

Background:

  • Human papillomavirus (HPV) is a common DNA virus causing warts in children.
  • While many infections resolve spontaneously via immune response, up to one-third persist beyond two years.
  • Current therapeutic options for pediatric HPV infections are diverse due to a lack of universally effective treatments.

Purpose of the Study:

  • To provide an updated review of human papillomavirus (HPV) and its therapeutic strategies in pediatric populations.
  • To highlight recent advancements in the understanding and management of HPV infections in children.

Main Methods:

  • Review of recent research on HPV therapies.
  • Analysis of emerging immunologic and destructive treatment modalities.
  • Evaluation of newly developed HPV vaccines for clinical application.

Main Results:

  • Significant research progress has been made in developing novel HPV therapies.
  • Destructive and immunologic treatment approaches show promise for managing pediatric warts.
  • Vaccines targeting specific genital HPV types are now entering clinical use.

Conclusions:

  • Future management of HPV infections in children will likely involve immune system modulation.
  • Vaccination and immunotherapies are expected to play a key role in controlling HPV.
  • These approaches may help prevent secondary HPV-related oncogenesis in the skin and cervix.
Abstract

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