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Updated: Aug 23, 2026
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Analysis of malignancy-associated DNA changes in interphase nuclei of buccal epithelium in persons with breast
Natalya Boroday1, Dmitriy Klyushin, Yuriy Petunin
1R.E.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv 03022, Ukraine. inst@iepor.kiev.ua
Aim:
To study from the point of view of statistical and geometrical theory of pattern recognition, the peculiarities of the distribution of optical density of DNA in the interphase nuclei of mammary buccal epithelium upon pathology.
Methods:
Cytogenetic investigation of buccal smears and computer-based image analysis were used.
Results:
It is shown that in malignant neoplasms of the mammary glands compared with its values in benign, the optical density of DNA in the nuclei of buccal epithelium increase in a range from 0.15 to 0.30 conventional units. The sensitivity of that criterium varied from 80.5% to 96.8%, and specificity was 92.3%.
Conclusion:
The method proposed may be recommended as an additional one for improvement of the diagnosis of mammary pathologies.
