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Updated: Aug 17, 2026

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
Published on: June 6, 2018
Effect of sildenafil citrate on penile erection of rhesus macaques
Xun-Bin Huang1, Cheng-Liang Xiong, Cheng-Gao Yu
1Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hang Kong Road, Wuhan 430030, China. huangxb@mails.tjmu.edu.cn
Aim:
To examine the effect of sildenafil citrate on penile erection of male rhesus macaque.
Methods:
Twenty Macaca mulatta were divided into the sildenafil treated and the control groups of 10 animals each. The penile size, the corpus cavernosal electromyogram (EMG) and the intra-corpus cavernosal pressure (ICP) were determined.
Results:
The diameter of penis and the ICP were significantly increased and the corpus cavernosal EMG significantly reduced in the sildenafil group.
Conclusion:
Sildenafil citrate increases the penile size and ICP and reduces the corpus cavernosal EMG in male rhesus macaque.
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