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Updated: Aug 23, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Analysis of Sciellin (SCEL) as a candidate gene in esophageal squamous cell carcinoma
Winston Corona1, Deepa J Karkera, Robert H Patterson
1Oncology Section, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA.
Background:
The aim of this study was to investigate whether a candidate gene, Sciellin (SCEL), mapping to the chromosome 13q21-q31 is mutated in esophageal cancer.
Materials And Methods:
The coding region and intron-exon junctions of SCEL were sequenced in 13 esophageal squamous cell cancers and matching normal esophageal samples to detect mutations.
Results:
Three single nucleotide polymorphisms were detected in SCEL of which two were silent mutations (L640L and H654H) and one missense mutation (R366K).
Conclusion:
Single nucleotide polymorphisms were detected in both matching tumor and normal esophageal tissues but no disease-associated mutations suggesting that SCEL is not a major factor in esophageal squamous cell carcinogenesis.
