Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Programmed cell death in trypanosomatids.

S C Welburn1, M A Barcinski, G T Williams

  • 1Tsetse Research Group, Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, 56 Dumbarton Road, Glasgow, UK. sue.welburn@tsetse.demon.co.uk

Parasitology Today (Personal Ed.)
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.

Oncogene·2024
Same author

Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy.

Scientific reports·2022
Same author

Molecular identification of bloodmeal sources and trypanosomes in Glossina spp., Tabanus spp. and Stomoxys spp. trapped on cattle farm settlements in southwest Nigeria.

Medical and veterinary entomology·2019
Same author

Identification and Sequencing of Bcl and Apaf1 Genes in the Common Carp, Cyprinus Carpio.

TheScientificWorldJournal·2018
Same author

People, Patches, and Parasites: The Case of Trypanosomiasis in Zimbabwe.

Human ecology: an interdisciplinary journal·2017
Same author

Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.

Oncogene·2016
Same journal

Immune effector mechanisms in parasitic infections.

Parasitology today (Personal ed.)·2006
Same journal

Nitric oxide in health and disease.

Parasitology today (Personal ed.)·2006
Same journal

Infection, oxford general practice series 40.

Parasitology today (Personal ed.)·2006
Same journal

Parasitism and the platyhelminthes.

Parasitology today (Personal ed.)·2006
Same journal

Reply.

Parasitology today (Personal ed.)·2006
Same journal

Waterborne cryptosporidiosis and the need for legislation.

Parasitology today (Personal ed.)·2006
See all related articles

Programmed cell death, or apoptosis, may not be exclusive to multicellular organisms. Some parasitic protozoa exhibit a similar cell suicide pathway, challenging previous biological assumptions.

Area of Science:

  • Cell Biology
  • Parasitology
  • Evolutionary Biology

Background:

  • Programmed cell death, including apoptosis, was traditionally linked to growth and development in multicellular organisms.
  • Recent research indicates that cell suicide mechanisms are also present in unicellular eukaryotes.
  • Parasitic protozoa, particularly vector-borne Trypanosomatids, are subjects of interest regarding cell death pathways.

Purpose of the Study:

  • To review the evidence for a cell suicide pathway in parasitic protozoa.
  • To discuss the implications of this pathway in Trypanosomatids.
  • To challenge the established view of programmed cell death evolution.

Main Methods:

  • Literature review of recent studies on programmed cell death in protozoa.

Related Experiment Videos

  • Comparative analysis of cell suicide mechanisms in metazoa and protozoa.
  • Discussion of the biological significance in vector-borne parasites.

    • Main Results:

    • Parasitic protozoa possess a cell suicide pathway analogous to metazoan apoptosis.
    • This pathway's existence suggests a broader evolutionary role for programmed cell death.
    • The implications for Trypanosomatids, including their biology and interaction with hosts, are significant.

    Conclusions:

    • Programmed cell death is not exclusive to multicellular organisms.
    • The cell suicide pathway in Trypanosomatids warrants further investigation.
    • This finding redefines our understanding of cell death evolution and its role in parasitic organisms.