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Modulation of host cell intracellular Ca2+.

M Olivier1

  • 1Centre de Recherche en Infectiologie, 9500, Centre Hospitalier de l'Université Laval, and Département de Microbiologie, Faculté de Médecine, Université Laval, 2705 boulevard Laurier, Ste-Foy, Québec, Canada. MOlivier@VMI.ULaval.CA

Parasitology Today (Personal Ed.)
|April 1, 1996
PubMed
Summary

Protozoan parasites manipulate host cell calcium (Ca2+) homeostasis for survival. This disruption contributes to disease pathogenesis and requires further investigation into its mechanisms.

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Area of Science:

  • Parasitology
  • Cell Biology
  • Immunology

Background:

  • Protozoan parasites evolve mechanisms to evade host immune responses.
  • Modulating host cell signaling pathways is a key survival strategy for parasites.
  • Altered calcium (Ca2+) homeostasis is a known consequence of parasitic invasion.

Purpose of the Study:

  • To review the role of protozoan parasites in disrupting host cell calcium homeostasis.
  • To highlight the significance of Ca2+ dysregulation in parasitic pathogenesis.
  • To emphasize the need for further research into the mechanisms of Ca2+ imbalance.

Main Methods:

  • Review of existing literature on protozoan parasite-host interactions.
  • Analysis of reported cases of calcium homeostasis alteration by parasites like Leishmania donovani, Trypanosoma cruzi, Plasmodium falciparum, and Entamoeba histolytica.

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  • Discussion of the implications of these alterations in disease.

    • Main Results:

    • Protozoan parasites actively modulate host cell transductional mechanisms.
    • Parasitic invasion leads to significant disturbances in host cell calcium homeostasis.
    • These calcium imbalances are directly linked to the observed pathogenesis in parasitic infections.

    Conclusions:

    • Disturbances in host cell calcium homeostasis are an early, inducible event during parasitic infections.
    • Understanding the mechanisms behind Ca2+ imbalance is crucial for addressing parasitic diseases.
    • Further investigation is warranted to elucidate these complex host-parasite interactions.