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Schistosomes and serpins: a complex business
J Modha1, M C Roberts, J R Kusel
1Division of Biochemistry and Molecular Biology, The Davidson Building, University of Glasgow, UK. gbca66@udcf.gla.ac.uk
Parasitology Today (Personal Ed.)
|March 1, 1996
Summary
Schistosome parasites actively manipulate host systems, not just defend themselves. Recent findings reveal surface-bound serine protease inhibitors (serpins) may be key to this exploitation for parasite survival and transmission.
Area of Science:
- Parasitology
- Immunology
- Biochemistry
Background:
- The host-parasite relationship in schistosomiasis was traditionally viewed as a one-sided battle, with the parasite merely surviving a hostile host environment.
- Recent research indicates a more complex, dynamic interaction where parasites actively exploit host physiological processes.
Purpose of the Study:
- To discuss the significance of newly identified schistosome surface serine protease inhibitors (serpins).
- To propose mechanisms by which these serpins facilitate parasite survival, maturation, and transmission by exploiting host homeostasis.
Main Methods:
- Review of recent literature on schistosome-host interactions.
- Analysis of the biochemical properties and potential functions of schistosome surface serpins.
Main Results:
- Identification of serine protease inhibitors (serpins) on the surface of schistosomes.
- Hypothesized role of these serpins in modulating host immune responses and physiological functions.
Conclusions:
- Schistosome parasites engage in sophisticated manipulation of host homeostatic mechanisms.
- Surface-expressed serpins represent a novel target for understanding and potentially disrupting the host-parasite interplay in schistosomiasis.