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P-glycoproteins in nematodes
1Department of Veterinary Pathology, University of Sydney, New South Wales, 2006, Australia.
Parasitology Today (Personal Ed.)
|January 1, 1994
Summary
P-glycoprotein (Pgp) is found in animals and nematodes. Researchers are investigating if Pgp contributes to anthelmintic resistance in parasites, alongside its normal cellular functions.
Area of Science:
- Biochemistry
- Parasitology
- Molecular Biology
Background:
- P-glycoprotein (Pgp) is an ATP-binding cassette integral membrane protein found widely in animals.
- Pgp homologues have been identified in nematodes.
- Pgp is implicated in drug resistance in parasitic protozoa like Plasmodium.
Purpose of the Study:
- To explore the potential involvement of P-glycoprotein in anthelmintic resistance.
- To discuss the normal cellular functions of P-glycoprotein.
Main Methods:
- Literature review and analysis of existing research on Pgp.
- Comparative genomics to identify Pgp homologues in nematodes.
Main Results:
- Pgp family members are present in nematodes.
- The role of Pgp in parasitic drug resistance is established in protozoa.
Conclusions:
- Further research is warranted to determine Pgp's role in anthelmintic resistance.
- Understanding Pgp's function is crucial for both parasite biology and drug development.