Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intra-membrane ligand diffusion and cell shape modulate juxtacrine patterning.

Steven D Webb1, Markus R Owen

  • 1Department of Mathematical Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK. s.d.webb@lboro.ac.uk

Journal of Theoretical Biology
|July 28, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Translating in vitro buccal permeation to in vivo and whole‑body exposure using in silico cell‑based and physiologically-based pharmacokinetic modelling.

International journal of pharmaceutics·2026
Same author

Virtual Clinical Trials of BMP4 Differentiation Therapy: Digital Twins to Aid Successful Glioblastoma Trial Design.

bioRxiv : the preprint server for biology·2025
Same author

Data derived extrapolation factors (DDEFs) for rat to human interspecies extrapolation for the HPPD inhibitor mesotrione.

Critical reviews in toxicology·2024
Same author

Elementary effects for models with dimensional inputs of arbitrary type and range: Scaling and trajectory generation.

PloS one·2023
Same author

Long-distance hormone transport via the phloem.

Journal of theoretical biology·2023
Same author

<i>In silico</i> evidence for the utility of parsimonious root phenotypes for improved vegetative growth and carbon sequestration under drought.

Frontiers in plant science·2022
Same journal

The male-biased sex ratio in humans and its role in the transition from promiscuity to pair bonding.

Journal of theoretical biology·2026
Same journal

Quantifying the counter-intuitive effects of vaccination by coupling the transmission dynamics of COVID-19 and the evolution of human behaviors.

Journal of theoretical biology·2026
Same journal

An integrative model of FGF2-induced signaling and muscle cell proliferation.

Journal of theoretical biology·2026
Same journal

A hybrid reaction-diffusion and mechanical stimulus model for mandibular bone remodeling under chewing and vibratory loading.

Journal of theoretical biology·2026
Same journal

Integrated tick management strategies in fragmented peridomestic environments.

Journal of theoretical biology·2026
Same journal

Joint likelihood-free inference of the number of selected single nucleotide polymorphisms and their selection coefficients in an evolving population.

Journal of theoretical biology·2026
See all related articles

Inhomogeneous protein distribution in cell membranes is crucial for pattern and polarity in developmental biology. Intra-membrane ligand transport drives long-wavelength patterns, essential for processes like wing hair polarization.

Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Biophysics

Background:

  • Pattern formation and planar polarity in epithelial tissues are fundamental to development.
  • Juxtacrine signaling via transmembrane ligands is a key mechanism, but previous models overlooked membrane inhomogeneity.
  • The role of protein distribution and polarity in cell-cell communication remains underexplored.

Purpose of the Study:

  • To investigate the impact of inhomogeneous protein and receptor distributions on juxtacrine signaling.
  • To determine the role of intra-membrane transport in pattern generation and polarity.
  • To model how ligand binding, production, and trafficking influence developmental patterning.

Main Methods:

  • Developed a computational model incorporating individual membrane segments and diffusive transport.

Related Experiment Videos

  • Included production terms with local and global responses to ligand binding.
  • Analyzed pattern formation under conditions of lateral induction and inhibition, considering biased ligand production and trafficking.

    • Main Results:

    • Intra-membrane ligand transport is essential for generating long-wavelength patterns.
    • Pattern formation during lateral induction fails without ligand transport.
    • Biased ligand production and trafficking can establish regular cellular polarity, mimicking Drosophila wing hair patterns.
    • Confirmed previous observations on pattern wavelengths for lateral inhibition (short-range) and lateral induction (long-range).

    Conclusions:

    • Inhomogeneous protein distributions and intra-membrane transport are critical for developmental patterning and planar polarity.
    • The model provides insights into how cell-cell communication mechanisms generate complex biological structures.
    • The findings have implications for understanding tissue development and polarization phenomena.