Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Macromolecular complexes regulating cardiac ryanodine receptor function.

Donald M Bers1

  • 1Department of Physiology, Loyola University Chicago, Stritch School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA. dbers@lumc.edu

Journal of Molecular and Cellular Cardiology
|July 28, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitoquinone Prevents Cardiac Dysfunction by Normalizing Mitochondrial ROS and Calcium Handling in Acute Myocardial Infarction.

Acta physiologica (Oxford, England)·2026
Same author

Mitochondrial protein OPA3 sustains cardiac function by regulating calcium handling in male mice.

Nature communications·2026
Same author

Dynamic visualization of physiological CaMKII activity using sensitive FRET biosensors.

bioRxiv : the preprint server for biology·2026
Same author

Targeting Arrhythmogenic Late Sodium Current by FHF1<sub>A</sub>-Derivative FixR in Heart Failure Cardiomyocytes.

Circulation research·2026
Same author

Empagliflozin restores cardiac function in obese-diabetic HFpEF mice but further alters gene expression.

Basic research in cardiology·2026
Same author

Ablation, percolation, and afterdepolarization.

Biophysical journal·2026

The cardiac ryanodine receptor (RyR) forms a complex with regulatory proteins, influencing heart function and arrhythmias. Understanding these interactions is key to cardiac signaling and disease mechanisms.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Biochemistry

Background:

  • The cardiac ryanodine receptor (RyR) is a critical Ca-release channel in the sarcoplasmic reticulum.
  • RyR plays a central role in myocyte excitation-contraction (E-C) coupling, cardiac arrhythmias, and pacemaker activity.
  • RyR functions within a large macromolecular complex containing numerous regulatory proteins.

Purpose of the Study:

  • To elucidate the physical and molecular nature of protein-protein interactions within the RyR complex.
  • To understand how this protein complex functionally modulates RyR activity.
  • To explore the role of local molecular signaling in cardiac function.

Main Methods:

  • The abstract does not specify methods, focusing on the description of the RyR complex and its interactions.
Keywords:
Non-programmatic

Related Experiment Videos

  • Further research would involve biochemical assays, structural biology, and physiological studies to investigate these interactions.
  • Analysis of protein-protein interaction networks and their functional consequences.

    • Main Results:

    • The RyR complex comprises various proteins like calmodulin, FKBP, kinases, phosphatases, and structural proteins (e.g., triadin, junctin, calsequestrin).
    • Information regarding the precise nature of these protein-protein interactions and their functional impact is still evolving.
    • The RyR complex is located near regulatory complexes of sarcolemmal Ca channels, suggesting localized signaling.

    Conclusions:

    • The RyR macromolecular complex is crucial for regulating cardiac Ca dynamics and function.
    • Understanding the intricate protein interactions within this complex is essential for deciphering cardiac arrhythmias and developing targeted therapies.
    • Local molecular signaling, centered around the RyR complex, is vital for cardiac E-C coupling.