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Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

Effect of clopidogrel pretreatment on periprocedural rise in C-reactive protein after percutaneous coronary

Deepak P Vivekananthan1, Deepak L Bhatt, Derek P Chew

  • 1Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Ohio 44195, USA.

The American Journal of Cardiology
|July 28, 2004
PubMed

Insights

Pretreating patients with clopidogrel significantly reduces C-reactive protein (CRP) levels following percutaneous coronary intervention. This pretreatment was independently linked to a 65% attenuation in the CRP increase after the procedure.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Percutaneous coronary intervention (PCI) can trigger an inflammatory response, indicated by elevated C-reactive protein (CRP).
  • Understanding interventions to mitigate this inflammatory marker is crucial for patient outcomes.

Purpose of the Study:

  • To investigate the impact of clopidogrel pretreatment on the periprocedural increase in C-reactive protein (CRP) after PCI.
  • To assess the independent association of clopidogrel pretreatment with CRP level changes post-PCI.

Main Methods:

  • Observational study analyzing CRP levels before and after PCI.
  • Statistical analysis, including multivariate modeling, was used to determine the effect of clopidogrel pretreatment.

Main Results:

  • Clopidogrel pretreatment demonstrated a significant attenuation of the periprocedural CRP increase, reducing it by 65%.
  • In a multivariate model, clopidogrel pretreatment remained independently associated with this reduction in CRP elevation.

Conclusions:

  • Clopidogrel pretreatment is an effective strategy to reduce the inflammatory response, as measured by CRP, following PCI.
  • The anti-inflammatory effect of clopidogrel pretreatment is significant and independently associated with reduced CRP levels post-PCI.

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