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Updated: Aug 23, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
EBV-associated nasopharyngeal carcinomas: from epidemiology to virus-targeting strategies
Pierre Busson1, Cécile Keryer, Tadamassa Ooka
1UMR 8126, CNRS and Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France. pbusson@igr.fr
Abstract:
Nasopharyngeal carcinoma is a human malignancy consistently associated with the Epstein-Barr virus. Exposure to non-viral carcinogens and genetic predisposition are other crucial etiologic factors. Tumor development appears to require the expression of a small subset of transforming viral RNAs and proteins with concomitant silencing of most other viral genes. Impairment of the interactions of viral proteins with cellular partners or disruption of viral latency might prove to be useful for novel therapeutic strategies.
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