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Monoolein cubic phases containing hydrogen peroxide

Jin-Chul Kim1, Keun Uk Lee, Won Cheol Shin

  • 1School of Biotechnology and Bioengineering, Kangwon National University, 192-1, Hyoja 2-dong, Chunchon, Kangwon-do 200-701, Republic of Korea. jinkim@kangwon.ac.kr

Colloids and Surfaces. B, Biointerfaces
|July 28, 2004
PubMed

Insights

Monoolein cubic phases loaded with hydrogen peroxide (H2O2) show potential as topical disinfectants. These phases exhibit good skin adhesion and controlled H2O2 release, with breakdown attributed to hydrolysis and oxidation.

Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Physical Chemistry

Background:

  • Monoolein (MO) cubic phases are self-assembling lipid structures with potential applications in drug delivery.
  • Understanding their stability and release kinetics is crucial for developing functional materials.

Purpose of the Study:

  • To investigate the properties of monoolein (MO) cubic phases hydrated with hydrogen peroxide (H2O2) solution.
  • To evaluate their thermal transitions, structural characteristics, H2O2 release profile, stability, and potential as a topical disinfectant.

Main Methods:

  • Preparation of MO cubic phases with 30wt.% aqueous phase (distilled water or 12wt.% H2O2).
  • Characterization using polarizing photomicroscopy, differential scanning calorimetry (DSC), small-angle X-ray scattering (SAXS), and 1H NMR spectroscopy.
  • Assessment of H2O2 release kinetics and phase stability at 45°C.
  • Measurement of tensile adhesive forces.

Main Results:

  • The cubic phase transitioned to a reversed hexagonal phase around 65°C.
  • SAXS indicated diamond surfaces for the cubic phases.
  • Controlled H2O2 release occurred over 40 hours, with ~50% released in the first 10 hours.
  • The cubic phase remained stable for 56 days at 45°C before breakdown, attributed to MO hydrolysis and oxidation.
  • The cubic phases exhibited higher tensile adhesive forces than polyacrylate skin patches.

Conclusions:

  • MO cubic phases containing H2O2 demonstrate controlled release and good stability, making them suitable for topical applications.
  • The observed breakdown mechanism involves hydrolysis and oxidation of MO.
  • These H2O2-loaded cubic phases show promise as effective topical disinfectant gels for wounded skin.

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