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Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
Alkaloids of Thalictrum angustifolium
Tawfeq A Al-Howiriny1, Michael A Zemaitis, Fu-Tyan Lin
1Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA.
Abstract:
Fractionation and chromatography of the ethanolic extract of the roots of Thalictrum angustifolium L. (Ranunculaceae) afforded five alkaloids: noroxyhydrastinine (1), O-methylthalicberine (2), berberine iodide (3), jatrorrhizine iodide (4), magnoflorine iodide (5). In addition, one simple aromatic compound, methyl-4-hydroxybenzoate (6), was also isolated. These compounds were identified via comparison of their spectral data with authentic compounds or spectra available within our laboratory. This is the first reported isolation of these compounds from this species.
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