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Published on: August 14, 2015
Lamotrigine-induced seizure aggravation and negative myoclonus in idiopathic rolandic epilepsy
Caterina Cerminara1, Maria Lucia Montanaro, Paolo Curatolo
1Department of Developmental Neurology and Psychiatry, Division of Neurosciences, Tor Vergata University, Rome, Italy.
Abstract:
The authors describe a paradoxical reaction to lamotrigine (LTG) treatment in a patient with idiopathic rolandic epilepsy characterized by seizure deterioration, the appearance of new seizure type, and transient cognitive impairment. This phenomenon was present at a low dose after a slow titration and promptly reverted on LTG discontinuation. This rare event may have similarities with carbamazepine-induced seizure worsening caused by the Na++ channel inhibitory effect of the two antiepileptic drugs.
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