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Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
Published on: October 27, 2014
New 2(3-->20)abeotaxane and 3,11-cyclotaxane from needles of Taxus cuspidata
Qing-Wen Shi1, Zuo-Ping Li, Ding Zhao
1Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medicinal University, 336 Zhongshan East Road, 050017, Shijiazhuang, Hebei, Province, People's Republic of China. qing_wen@hotmail.com
Abstract:
Two new taxoid metabolites, 2alpha,7beta,10beta-triacetoxy-5alpha,13alpha-dihydroxy-2(3-->20)abeotaxa-4(20),11-dien-9-one (1) and 2alpha-acetoxy-5alpha-cinnamoyloxy-9alpha,10beta-dihydroxy-3,11-cyclotax-4(20)-en-13-one (2), were isolated from the methanol extract of needles of the Japanese yew, Taxus cuspidata.
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