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Updated: Aug 23, 2026
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Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification
Published on: July 25, 2025
The effect of sevoflurane on rat liver mitochondrial respiration
H Yokoyama1, N Kubota, T Shibata
1Department of Anesthesiology, St Marianna University, School of Medicine, Kawasaki, Japan.
Journal of Anesthesia
|April 1, 1993
Abstract:
The effect of sevoflurane on rat liver mitochondrial respiration has been investigated with a Clark type oxygen electrode at 25 degrees C, pH 7.4. The higher susceptibility of NADH-linked substrate (glutamate) oxidation (with respect to succinate oxidation) to the damages by sevoflurane has been confirmed.
