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Updated: Aug 23, 2026

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
Published on: September 11, 2018
Systemic administration of procaine suppresses the somato-sympathetic reflex discharges in anesthetized cats
1Department of Anesthesiology, Beijing Medical University First Hospital, Beijing, the People's Republic of China.
Abstract:
Somato-sympathetic reflex discharges (SSRDs) which were induced from the lumbar sympathetic truck elicited by train pulse stimulation of femoral nerves in anesthetized cats were examined during and after intravenous infusion of 1 mg.kg(-1).min(-1) of procaine. The infusion demonstrated that amplitudes were suppressed with prolonged latencies and/or their tendencies in A- and C-reflex potentials of SSRDs. Heart rate and blood pressure decreased slightly, and the decreases correlated with time courses of suppressed SSRDs. These results suggest that the systemic procaine infusion may be a reliable method to alleviate somato-sympathetic reflexes under such conditions as extreme stimulation of somatic afferent nerves observed in surgical procedures.
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