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Glucose 6 phosphate dehydrogenase deficiency in adults

Monir Khan1

  • 1Department of Health, THQ Hospital, Dir (upper). drmonir99@yahoo.com

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|July 29, 2004
PubMed

Insights

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common cause of anemia in adults. Early recognition and avoiding certain medications can prevent serious hemolytic complications.

Area of Science:

  • Medical Genetics
  • Hematology
  • Clinical Biochemistry

Background:

  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common inherited enzyme disorder.
  • Anemia is a significant public health concern, particularly in certain populations.
  • Identifying the prevalence of G6PD deficiency in anemic patients is crucial for effective management.

Purpose of the Study:

  • To determine the frequency of G6PD deficiency in adult patients presenting with anemia.
  • To investigate the association between G6PD deficiency and anemia.

Main Methods:

  • A case-review of 18 months of admission data from District Headquarter Hospital Batkhela.
  • Anemia defined by WHO criteria (hemoglobin < 11.3 gm%).
  • G6PD activity measured using the Sigma dye decolorisation method; patients >13 years included.

Main Results:

  • Out of 3600 admitted patients, 1440 were anemic, and 49 were G6PD deficient.
  • The frequency of G6PD deficiency in anemic patients was 3.4%; overall frequency was 1.36%.
  • Males showed 3% and females 6% G6PD deficiency; antimalarials and sulfonamides were common triggers for hemolysis, leading to anemia and jaundice.

Conclusions:

  • G6PD deficiency is a significant cause of anemia, often triggered by medications.
  • Early diagnosis and judicious use of drugs can prevent severe hemolytic complications.
  • Awareness of G6PD deficiency is essential for healthcare providers managing anemic patients.
Abstract

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