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Updated: Aug 23, 2026

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
Feeding induces expression of heat shock proteins that reduce oxidative stress
Kensaku Katsuki1, Mitsuaki Fujimoto, Xiu-Ying Zhang
1Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami-Kogushi 1-1-1, Ube 775-8505, Japan.
Abstract:
Heat shock proteins (Hsps) are induced in response to various kinds of environmental and physiological stresses. However, it is unclear whether Hsps play roles in protecting cells in the digestive organs against xenobiotic chemicals. Here, we found that feeding induces expression of a set of Hsps specifically in the mouse liver and intestine by activating heat shock transcription factor 1 (HSF1). In the liver, HSF1 is required to suppress toxic effects of electrophiles, which are xenobiotic chemicals causing oxidative stress. We found that overexpression of Hsp27, which elevates cellular glutathione level, promotes survival of culture cells exposed to electrophiles. These results suggest a novel mechanism of cell protection against xenobiotic chemicals in the food.
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