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Does maternal smoking influence leptin levels in term, appropriate-for-gestational-age newborns?

I M C G Pardo1, B Geloneze, M A Tambascia

  • 1Department of Pediatrics, Faculty of Medical Sciences University of Campinas-UNICAMP, Rua Souza Pereira 138, São Paulo 18010-320, Brazil.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|July 29, 2004
PubMed

Insights

Maternal smoking during pregnancy did not alter cord blood leptin levels in newborns. This study found no significant difference in leptin concentrations between infants of smoking and non-smoking mothers.

Area of Science:

  • Endocrinology
  • Perinatal Medicine
  • Public Health

Background:

  • Leptin, a hormone from adipose tissue and placenta, influences neonatal growth.
  • Maternal health during pregnancy can impact fetal development and birth outcomes.

Purpose of the Study:

  • To examine the association between maternal smoking and cord blood leptin levels.
  • To determine if maternal smoking affects term, appropriate-for-gestational-age infants' leptin concentrations.

Main Methods:

  • Comparative study of term, appropriate-for-gestational-age newborns.
  • Two groups: infants of smoking mothers (n=19) and non-smoking mothers (n=91).
  • Leptin levels measured via radioimmunoassay; anthropometric data collected.

Main Results:

  • No significant difference in cord blood leptin levels between groups (p=0.915).
  • Leptin concentrations positively correlated with ponderal index (p < 0.01) and gestational age (p < 0.05).

Conclusions:

  • Maternal smoking during pregnancy does not appear to affect cord blood leptin levels in term, appropriate-for-gestational-age infants.
  • Further research may explore other factors influencing leptin in this population.
Abstract

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