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Second-trimester amniotic fluid interleukin-10 concentration predicts preterm delivery.

J Apuzzio1, Ying Chan, A Al-Khan

  • 1Department of Obstetrics, Gynecology and Women's Health, New Jersey Medical School, Newark, New Jersey, USA.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|July 29, 2004
PubMed
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Elevated levels of both interleukin-6 (IL-6) and interleukin-10 (IL-10) in second-trimester amniotic fluid were observed in women who later experienced preterm delivery. Low IL-10 is not the cause of preterm labor.

Area of Science:

  • Reproductive biology
  • Immunology
  • Obstetrics

Background:

  • Interleukin-6 (IL-6) is an inflammatory cytokine linked to preterm labor.
  • Interleukin-10 (IL-10) is an anti-inflammatory cytokine that can inhibit other cytokine synthesis.

Purpose of the Study:

  • To investigate the hypothesis that low amniotic fluid IL-10 in early pregnancy precedes preterm labor.
  • To explore the relationship between IL-6, IL-10 levels, and preterm delivery.

Main Methods:

  • Amniotic fluid samples were collected from 96 women undergoing genetic amniocentesis (15-23 weeks' gestation).
  • Levels of IL-6 and IL-10 were quantified using immunoassay.
  • Data were correlated with pregnancy outcomes and patient demographics.

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Main Results:

  • Fifteen patients delivered before 36 weeks; 81 delivered after 36 weeks.
  • Both IL-10 and IL-6 concentrations showed an inverse correlation with gestational age at delivery.
  • Higher levels of both cytokines were found in women who delivered preterm.

Conclusions:

  • Elevated second-trimester amniotic fluid IL-6 and IL-10 levels are associated with subsequent preterm delivery.
  • Low amniotic fluid IL-10 production in the second trimester does not appear to be a direct cause of preterm labor.