Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet activating factor antagonist enhances lung preservation.

P C Corcoran1, Y Wang, N M Katz

  • 1Department of Surgery, Georgetown University Medical Center, Washington, D.C. 20007.

The Journal of Surgical Research
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defining oliguria during cardiopulmonary bypass and its relationship with cardiac surgery-associated acute kidney injury.

British journal of anaesthesia·2016
Same author

One-year heterotopic cardiac xenograft survival in a pig to baboon model.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013
Same author

B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2011
Same author

Surgical and nonsurgical complications of a pig to baboon heterotopic heart transplantation model.

Transplantation proceedings·2010
Same author

Left ventricular pressure measurement by telemetry is an effective means to evaluate transplanted heart function in experimental heterotopic cardiac xenotransplantation.

Transplantation proceedings·2010
Same author

Pentalogy of Cantrell associated with hypoplastic left heart syndrome.

Pediatric cardiology·2007

This study shows that using BN 52021, a platelet-activating factor antagonist, improves lung preservation during canine lung transplantation. The treatment enhanced oxygenation, reduced pulmonary vascular resistance, and increased compliance in transplanted lungs.

Area of Science:

  • Cardiovascular and Respiratory System Physiology
  • Immunology and Inflammation
  • Transplantation Science

Background:

  • Platelet-activating factor (PAF) is a key mediator in immune and inflammatory responses.
  • PAF's effects mimic physiological changes seen in post-transplant pulmonary dysfunction.
  • Investigating PAF antagonists may offer strategies to improve lung transplant outcomes.

Purpose of the Study:

  • To evaluate the efficacy of a specific PAF antagonist, BN 52021, in enhancing lung preservation during allotransplantation.
  • To test the hypothesis that BN 52021 improves lung function post-transplant in canines.
  • To assess the impact of BN 52021 on pulmonary hemodynamics and gas exchange.

Main Methods:

  • Canine left lung allotransplantation model utilized, with 12 pairs of canines.

Related Experiment Videos

  • Pulmonary artery flushing performed with modified Euro-Collins (EC) solution.
  • Experimental group received EC solution with BN 52021; control group received EC solution alone.

    • Main Results:

    • BN 52021 administration improved transplant lung oxygenation (pulmonary venous oxygen tension).
    • Pulmonary vascular resistance was significantly reduced in the BN 52021 treatment group.
    • Dynamic pulmonary compliance of the transplanted lung was markedly increased with BN 52021.

    Conclusions:

    • The PAF antagonist BN 52021 significantly improves lung preservation in a canine lung transplantation model.
    • BN 52021 demonstrates potential in mitigating post-transplant pulmonary dysfunction.
    • This study supports further investigation of PAF antagonists for enhancing lung transplant viability and function.