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Related Experiment Videos

Suppressor T cells in human diseases.

Clare Baecher-Allan1, David A Hafler

  • 1Harvard Medical School, 77 Ave. Louis Pasteur, Boston, MA 02115, USA. callan@rics.bwh.harvard.edu

The Journal of Experimental Medicine
|July 29, 2004
PubMed
Summary
This summary is machine-generated.

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Suppressor CD4(+) CD25(+) T cells play a key role in regulating immune responses. Altered function of these cells is increasingly linked to human autoimmune, inflammatory, and infectious diseases.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Central and peripheral tolerance are crucial for immune homeostasis.
  • CD4(+) CD25(+) T cells are recognized as key regulators of immune responses.

Purpose of the Study:

  • To investigate the role of suppressor CD4(+) CD25(+) T cells in human immune regulation.
  • To explore the link between altered CD4(+) CD25(+) T cell function and various diseases.

Main Methods:

  • Analysis of human autoimmune diseases and HIV cases.
  • Investigation of CD4(+) CD25(+) T cell function in disease contexts.

Main Results:

  • Recent investigations suggest an important role for suppressor CD4(+) CD25(+) T cells.
  • Evidence indicates altered CD4(+) CD25(+) T cell function is implicated in disease.

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Conclusions:

  • Suppressor CD4(+) CD25(+) T cells are vital for immune regulation.
  • Dysfunctional CD4(+) CD25(+) T cells are implicated in a broad spectrum of human inflammatory and infectious diseases.