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Pediatric tonsillopharyngitis--an evaluation of cefprozil in Indian patients
Nomeeta Gupta1, Abhijit Mukherjee, A K Moharana
1Batra Hospital & Medical Research Center, New Delhi, India.
Insights
Cefprozil effectively treats pediatric tonsillopharyngitis, achieving high clinical cure and bacterial eradication rates. This cephalosporin antibiotic demonstrates excellent tolerability in children, offering a valuable option for bacterial infections.
Area of Science:
- Pediatric Infectious Diseases
- Bacteriology
- Pharmacology
Background:
- Bacterial infections in children pose treatment challenges due to resistant strains.
- Streptococcal tonsillopharyngitis is a common pediatric infection.
- Cefprozil, a third-generation cephalosporin, has shown efficacy in treating this condition.
Purpose of the Study:
- To evaluate the efficacy and tolerability of cefprozil in pediatric tonsillopharyngitis.
- To assess clinical cure and bacteriological eradication rates.
- To determine the overall safety profile of cefprozil in children.
Main Methods:
- Prospective, open-label, non-comparative, multicenter study.
- Inclusion of 316 pediatric patients with tonsillopharyngitis (mean age 6.61 years).
- Administration of cefprozil suspension at 15 mg/kg/day in two divided doses for 10 days.
Main Results:
- Achieved a clinical cure rate of 96.6%.
- Demonstrated a bacteriological eradication rate of 94.29%.
- Physician-assessed tolerability was rated as excellent or very good in 84% of cases.
Conclusions:
- Cefprozil is an excellent therapeutic option for pediatric tonsillopharyngitis.
- The drug exhibits superior microbiological and clinical activity.
- Cefprozil possesses an expanded spectrum of activity, enhancing its utility.
Objective:
The emergence of penicillin resistant strains and the presence of co-pathogens have made the treatment of bacterial infections in children a challenge. Streptococcal tonsillopharyngitis, which is a common infection has been well treated with cefprozil, a novel third generation cephalosporin. The aim of the present study was to evaluate cefprozil in pediatric tonsillopharyngitis. An assessment of the clinical cure and bacteriological eradication rates and an overall tolerability was made.
Methods:
It was a prospective, open, non-comparative multicentric study. 316 children (mean age 6.61 years) with tonsillopharyngitis were included. Patients were given cefprozil susp 15 mg/kg/day in two divided doses a day for 10 days.
Results:
A clinical cure of 96.6% and bacteriological eradication of 94.29% was achieved with cefprozil. Overall tolerability of cefprozil was assessed by physicians and 46% rated tolerability of cefprozil as excellent, 38% as very good, 10% as good, 6% as fair and none as poor.
Conclusion:
Cefprozil has been found to be an excellent drug of superior microbiological and clinical activity in the treatment of pediatric patients with tonsillopharyngitis. The drug also has an expanded spectrum.
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