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Related Experiment Videos

Cranial computed tomography in partial motor seizures.

Jageer Hussain1, S Srinivasan, V Tiroumourougane Serane

  • 1Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

Indian Journal of Pediatrics
|July 29, 2004
PubMed
Summary

In developmentally normal children with partial motor seizures, computed tomography revealed single ring enhancing lesions (SREL) often resolve with antiepileptic drugs alone. Awareness of disappearing SREL avoids unnecessary antitubercular or anticysticercal therapy.

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Area of Science:

  • Pediatric Neurology
  • Neuroradiology
  • Neuroimaging

Background:

  • Partial motor seizures in children can be associated with intracranial structural lesions.
  • Developmentally normal children with seizures require accurate diagnosis and appropriate management.
  • Computed tomography (CT) is a key imaging modality for evaluating brain lesions.

Purpose of the Study:

  • To determine the pattern of intracranial structural lesions in developmentally normal children experiencing partial motor seizures using CT.
  • To observe the changes in single ring enhancing lesions (SREL) over time, with or without specific treatments.

Main Methods:

  • A cohort of developmentally normal children aged 1-12 years with partial motor seizures were evaluated.
  • Clinical examination, investigations for tuberculosis and cysticercosis, and CT scans were performed.

Related Experiment Videos

  • Children with SREL underwent repeat CT scans after 6 months, with management including anticonvulsants and, if indicated, antitubercular or anticysticercal therapy.

    • Main Results:

    • CT scans showed abnormalities in 68% of children, with SREL being the most common finding (75 children).
    • Parietal lobe was the most frequent location for SREL (65 cases).
    • In children treated only with antiepileptic drugs, 32 out of 41 with SREL showed a decrease in lesion size on repeat CT, while 9 had no change.

    Conclusions:

    • Single ring enhancing lesions (SREL) in developmentally normal children with partial motor seizures may resolve spontaneously or with anticonvulsant therapy alone.
    • Recognizing the potential for SREL resolution is crucial to prevent unnecessary and potentially harmful antitubercular or anticysticercal treatments.
    • Management should prioritize anticonvulsant therapy, reserving specific anti-infective treatments for confirmed cases.