Cytochrome P450 CYP1B1 activity in renal cell carcinoma

M C E McFadyen1, W T Melvin, G I Murray

  • 1Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK. m.mcfadyen@abdn.ac.uk

Summary

Active CYP1B1, an enzyme overexpressed in kidney cancer, was found in 70% of renal cell carcinoma (RCC) tumors. This enzyme metabolizes anticancer drugs, suggesting CYP1B1 as a potential therapeutic target for improving RCC treatment.

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