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Intravenous hyoscine as a premedication for colonoscopy: a randomized double-blind controlled trial.
K Y Yoong1, D Perkin, J Portal
1Kingston Hospital NHS Trust, Kingston upon Thames, Surrey, UK. kevin.yoong@kingstonhospital.nhs.uk
Endoscopy
|July 29, 2004
Summary
This study found no significant benefit of using hyoscine before colonoscopy procedures. Hyoscine premedication did not improve procedure time or success rates for caecal intubation in a hospital setting.
Area of Science:
- Gastroenterology
- Clinical Pharmacology
Background:
- Antispasmodic use for colonoscopy varies globally and is debated.
- Hyoscine's role as a premedication for colonoscopy lacks clear evidence.
Purpose of the Study:
- To evaluate the objective benefits of hyoscine premedication for colonoscopy.
- To assess hyoscine's impact on procedure efficiency and success rates.
Main Methods:
- Prospective randomized controlled trial.
- Day-case patients undergoing colonoscopy were allocated to receive intravenous hyoscine or placebo.
- 61 patients received hyoscine, and 56 received placebo.
Main Results:
- No statistically significant difference in median colonoscopy time (hyoscine: 9.7 min vs. placebo: 8.3 min).
- No significant difference in median total procedure time (hyoscine: 14.8 min vs. placebo: 13.8 min).
- Caecal intubation success rates showed no significant difference (P < 0.06), though a type II error is possible due to sample size.
Conclusions:
- Routine hyoscine premedication offers no clear advantage for colonoscopy in a district general hospital.
- Further research may be needed to definitively rule out benefits in specific populations.