Related Experiment Video
Updated: Aug 23, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Synthesis and antiviral evaluation of some novel tricyclic pyrazolo[3,4-b]indole nucleosides
John D Williams1, John C Drach, Leroy B Townsend
1Department of Medicinal Chemistry, College of Pharmacy University of Michigan, Ann Arbor, Michigan 48109-1078, USA.
Abstract:
Novel pyrazolo[3,4-b]indole nucleoside analogs were synthesized from the corresponding 3-formyl-2-chloroindole and 3-cyano-2-chloroindole nucleosides by treatment with hydrazine. Very few examples of pyrazolo[3,4-b]indole heterocycles have been published in the literature and this is the first synthesis of nucleoside analogs containing this heterocycle. These new pyrazolo[3,4-b]indole nucleosides were active against human cytomegalovirus and herpes simplex virus type 1, but this activity was not well separated from cytotoxicity.
Related Concept Videos
Antiviral Nucleoside Inhibitors
DNA Base Pairing
Inhibitors Of Virion Release
Inhibitors of Viral Protein Synthesis
Biosynthesis of Nucleic Acids
Inhibitors of Virion Maturation and Assembly
