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Effect of budesonide aqueous nasal spray on hypothalamic-pituitary-adrenal axis function in children with allergic

Kenneth T Kim1, Nathan Rabinovitch, Thomas Uryniak

  • 1Allergy, Asthma & Respiratory Care Medical Center, Long Beach, California 90806, USA. drkkim@wcctrials.com

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|July 30, 2004
PubMed

Insights

Budesonide aqueous nasal spray is safe for young children with allergic rhinitis. This study found no significant impact on hypothalamic-pituitary-adrenal (HPA) axis function in children aged 2-5 years.

Area of Science:

  • Pediatric Allergy and Immunology
  • Endocrinology
  • Pharmacology

Background:

  • Intranasal corticosteroids are standard for adult allergic rhinitis.
  • Pediatric systemic corticosteroid exposure raises safety concerns.
  • Evaluating HPA axis function is crucial for pediatric corticosteroid safety.

Purpose of the Study:

  • To assess the impact of budesonide aqueous nasal spray on HPA axis function in young children with allergic rhinitis.
  • To determine safety and tolerability of budesonide in pediatric patients.
  • To evaluate effects at the recommended once-daily dose.

Main Methods:

  • A 6-week, multicenter, double-blind, placebo-controlled study.
  • 78 children aged 2-5 years with allergic rhinitis participated.
  • HPA axis function assessed via plasma cortisol levels post-cosyntropin stimulation.

Main Results:

  • No significant differences in plasma cortisol levels between budesonide and placebo groups.
  • HPA axis function remained unaffected in the budesonide treatment group.
  • Safety and tolerability profiles were comparable to placebo.

Conclusions:

  • Budesonide aqueous nasal spray is safe and well-tolerated in children aged 2-5 years.
  • No measurable suppressive effects on HPA axis function were observed.
  • Supports the use of budesonide for pediatric allergic rhinitis.
Abstract

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