Related Experiment Video
Updated: Jul 19, 2026

Visualizing Single Molecular Complexes In Vivo Using Advanced Fluorescence Microscopy
Published on: September 8, 2009
Doxorubicin accumulation in individually electrophoresed organelles
Adrian B Anderson1, Guohua Xiong, Edgar A Arriaga
1Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Abstract:
We report the doxorubicin content in individual organelles following their capillary electrophoretic separation and illustrate that chemical accumulation at the subcellular level is highly heterogeneous. In individual mitochondria from cultured human leukemia cells DOX amount is around 50 zmol, 2 orders of magnitude higher than expected from diffusion during drug treatment, and spans 2 orders of magnitude.
More Related Videos
Related Concept Videos
Vesicular Tubular Clusters
With the help of motor proteins such...
Cell Motility through Blebbing
Blebbing Through the Matrix
In multicellular...
Concentration Cells
Cell Inclusions

