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Published on: July 11, 2012
Amino acid N-carboxyanhydrides: activated peptide monomers behaving as phosphate-activating agents in aqueous
Jean-Philippe Biron1, Robert Pascal
1Organisation Moléculaire Evolution et Matériaux Fluorés UMR 5073 - CC 017, Département de Chimie, Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier, France.
Abstract:
The hydrolysis of valine N-carboxyanhydride (NCA) in aqueous phosphate buffers was shown to proceed through nucleophilic catalysis via an aminoacyl phosphate intermediate that displays phosphorylating capabilities through a potentially prebiotic process that simulates modern biochemical metabolic pathways.
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