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The occurrence in mice of facial and mandibular abscesses associated with Staphylococcus aureus
Laboratory Animals
|July 1, 1978
Abstract:
Swellings affecting the face and jaws of a strain of outbred BSVS mice are described. The swellings consisted of multiple abscesses which were most commonly associated with the mandible. Staphylococcus aureus of a single phage type was isolated from the abscesses. It is suggested that the organisms gained entry through the oral mucosa.
Insights
Facial and jaw swellings in BSVS mice were caused by Staphylococcus aureus abscesses, primarily in the mandible. The bacteria likely entered through the oral mucosa, leading to these infections.
Area of Science:
- Veterinary Pathology
- Microbiology
- Animal Models
Background:
- Facial and jaw swellings can indicate underlying infections in animal models.
- Bacterial abscesses are a common pathological finding.
Purpose of the Study:
- To describe the characteristics of facial and jaw swellings in a specific mouse strain.
- To identify the causative agent and potential route of infection.
Main Methods:
- Clinical observation of swellings in outbred BSVS mice.
- Isolation and identification of bacteria from abscesses.
- Phage typing of isolated bacteria.
Main Results:
- Multiple abscesses were observed, predominantly affecting the mandible.
- Staphylococcus aureus, belonging to a single phage type, was consistently isolated.
- No other bacterial species were identified.
Conclusions:
- Staphylococcus aureus is the causative agent of these mandibular abscesses in BSVS mice.
- The oral mucosa is the likely portal of entry for the bacteria.
- This provides insight into Staphylococcus aureus infections in mouse models.