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Synthesis and identification of two potential oxidation degradants of oxymetazoline
Ian P Leader1, John Halket, Paul Finch
1Royal Holloway, Egham TW20 0EX, UK. leader.i@pg.com
Abstract:
Two potential oxidation degradants of oxymetazoline have been isolated by liquid chromatography and monitored by electrospray single quadrupole mass spectrometry. The structures of the products are shown to be oxymetazoline N-oxide and hydroxyamine by multiple-stage fragmentation ion trap mass spectrometry. The product ion spectra were installed in a library database and the library was used to examine an aged commercial product; one of the degradants was detected, but at a level of less than 0.1% of the parent.
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