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Published on: August 18, 2016
[Sudden death by coronary spasm: a particular and often unrecognised clinical entity]
P Godon1, T Abdelkrim, J R Caignault
1Service de cardiologie, hôpital d'instruction des Armées Desgenettes, Lyon. patrick.godon@wanadoo.fr
Insights
Coronary spasm is an underestimated cause of sudden cardiac death. Long-term calcium antagonist therapy is effective in preventing recurrence, with angioplasty as a second-line treatment.
Area of Science:
- Cardiology
- Cardiac Electrophysiology
Background:
- Sudden cardiac death (SCD) remains a significant clinical challenge.
- Coronary artery spasm is a potential, often overlooked, cause of SCD.
Observation:
- Three cases of resuscitated SCD were investigated.
- Coronary angiography with ergometric testing confirmed coronary spasm in all cases.
- Electrophysiological studies were normal in two patients.
Findings:
- Long-term calcium antagonist therapy was initiated for all patients.
- One patient underwent successful coronary angioplasty.
- Follow-up (6 months to 3 years) showed no recurrence or arrhythmias.
Implications:
- Coronary spasm is a likely underdiagnosed etiology of SCD.
- Medical management with calcium antagonists is the primary treatment.
- Percutaneous coronary intervention and defibrillator implantation are reserved for refractory cases.
Abstract:
The authors report 3 cases of resuscitated sudden death in which the investigations clearly showed coronary spasm. This was demonstrated by systematic coronary angiography with an ergometric test. Two patients underwent electrophysiological investigations which were normal. The three patients were prescribed long-term calcium antagonist therapy and one of them underwent coronary angioplasty. With a follow-up of 6 months to 3 years, there was no clinical recurrence or documented arrhythmia. A review of the literature shows that this is a cause of sudden death which is probably underestimated and unrecognised. Electrophysiological investigations often give disappointing results and medical therapy is the keystone of treatment. Coronary angioplasty and implantation of an automatic defibrillator are second-line treatments reserved to forms refractory to medical therapy.
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