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Published on: March 24, 2015
An immunoglobulin-like antigen in human cell lines and sera of cancer patients
1Research Institute of Cancerogenesis, All-Union Cancer Research Center, Academy of Medical Sciences, Moscow, CIS.
Abstract:
Different sera from cancer patients were tested for the presence of C1-GMA, an antigen described by us, which was shared by HeLa-like human cell lines and gastric mucosa. Using the immunodiffusion test, dot-blotting and electrophoresis followed by immunoblotting, we failed to reveal the antigen in the sera of patients. However, an Ig-like 56-60 kD antigen was found in the sera of patients with ovary and stomach carcinoma and lymphoid tumors. The Ig-like antigen was also revealed in 2 out of 5 tested human cell lines of non-leukocyte origin (HEp-2 and E16-B).
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