Related Experiment Video

Updated: Aug 23, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

[Novel angiogenesis inhibitors for molecular target therapy of cancer]

Hiroyuki Osada1, Hideaki Kakeya

  • 1Antibiotics Laboratory, Discovery Research Institute, RIKEN.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|July 31, 2004
PubMed

Insights

Angiogenesis inhibitors show promise in cancer therapy by targeting tumor blood vessel growth. Further research is needed to identify efficacy markers and optimal combinations for clinical use.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Context:

  • Tumor growth and metastasis rely on angiogenesis, the formation of new blood vessels.
  • Molecular targets for inhibiting angiogenesis are emerging from studies on tumor and endothelial cells.

Purpose:

  • To review promising angiogenesis inhibitors and their molecular targets currently in clinical trials.
  • To highlight the challenges and significance of clinical evaluation for anti-angiogenic therapies.

Summary:

  • Angiogenesis inhibitors, including anti-angiogenic and anti-vascular targeting agents, are promising cancer chemotherapy drugs.
  • Current challenges include the lack of surrogate markers for therapeutic efficacy and establishing effective combinations with other treatments.
  • This review focuses on drugs in clinical trials, their targets, and the importance of clinical evaluation.

Impact:

  • Advances in anti-angiogenic therapy could lead to more effective cancer treatments.
  • Identifying reliable efficacy markers will improve patient selection and treatment monitoring.
  • Optimizing combination therapies will enhance the overall efficacy of cancer treatment strategies.

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