Monoclonal antibodies distinguishing between two rat pancreatic carcinoma cell lines with different metastatic capacities
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Updated: Aug 18, 2026
A Preclinical Murine Model of Hepatic Metastases
Published on: September 27, 2014
1Medical Academy, National Oncological Centre, Sofia, Bulgaria.
Abstract:
Two new monoclonal antibodies, E5/E10 and E10/B4, were raised which reacted with surface antigens on the metastatic rat pancreatic adenocarcinoma cell line ASML, but not with antigens localized on the cell surface of the nonmetastatic rat pancreatic adenocarcinoma line AS. These two monoclonal antibodies are of the IgG1 subclass and recognize protein bands with molecular weight 28,000 and 35,000 D. E5/E10 and E10/B4 cross-reacted only with antigens on the human colon cancer cell line HT-29, as well as with normal rat kidney.
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